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Eczema Area and Severity Index

Physician-Reported Clinical Assessment

The recommended core instrument for measuring clinical signs of atopic dermatitis, endorsed by the HOME initiative. Evaluates four body regions across four severity characteristics with support for adult and pediatric weight sets.

Developed in partnership withDermi

About the EASI

Severity Bands

Score RangeClassification
0Clear
0.1 – 1Almost clear
1.1 – 7Mild
7.1 – 21Moderate
21.1 – 50Severe
50.1 – 72Very severe

Clinical Background

The EASI is the recommended core instrument for measuring clinical signs in atopic dermatitis clinical trials, as endorsed by the Harmonising Outcome Measures for Eczema (HOME) initiative. It was developed by modifying the PASI scoring system for use in eczema. The EASI evaluates four body regions (head/neck, upper extremities, trunk, lower extremities) across two domains: percentage of body surface area affected (scored 0 to 6) and intensity of four lesional signs, erythema, edema/papulation, excoriation, and lichenification (each scored 0 to 3).

Each region is weighted by its proportion of total body surface area: head/neck = 0.1, upper extremities = 0.2, trunk = 0.3, lower extremities = 0.4 for adults. For children under 8 years, the weights adjust to 0.2, 0.2, 0.3, 0.3 respectively, reflecting the proportionally larger head in younger children. The theoretical maximum score is 72.

The EASI has demonstrated high content validity, construct validity, internal consistency, and sensitivity to change. It was selected by the HOME initiative after review of more than 16 instruments as having the best overall psychometric properties. Administration time is approximately 6 minutes by a trained investigator.

References

  1. Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The Eczema Area and Severity Index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10(1):11-18. doi:10.1034/j.1600-0625.2001.100102.x
  2. Schmitt J, Spuls PI, Thomas KS, et al.. The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials. J Allergy Clin Immunol. 2014;134(4):800-807. doi:10.1016/j.jaci.2014.07.043
  3. Leshem YA, Hajar T, Hanifin JM, Simpson EL. What the EASI score tells us about the severity of atopic dermatitis: an interpretability study. Br J Dermatol. 2015;172(5):1353-1357. doi:10.1111/bjd.13662
  4. Hanifin JM, Baghoomian W, Grinich E, Leshem YA, Jacobson M, Simpson EL. The Eczema Area and Severity Index - A Practical Guide. Dermatitis. 2022;33(3):187-192. doi:10.1097/der.0000000000000895
  5. Schmitt J, Langan S, Deckert S, et al.. Assessment of clinical signs of atopic dermatitis: a systematic review and recommendation. J Allergy Clin Immunol. 2013;132(6):1337-1347. doi:10.1016/j.jaci.2013.07.008

Frequently Asked Questions about the EASI

The Eczema Area and Severity Index (EASI) is the recommended core instrument for measuring clinical signs in atopic dermatitis, endorsed by the Harmonising Outcome Measures for Eczema (HOME) initiative. It evaluates four body regions across the percentage of body surface area affected and the intensity of four lesional signs: erythema, edema/papulation, excoriation, and lichenification.
For each of the four body regions, the area of involvement is scored from 0 to 6 and multiplied by the sum of four severity scores (erythema, edema/papulation, excoriation, and lichenification, each scored 0 to 3). Each region is weighted by its proportion of total body surface area. For adults: head/neck = 0.1, upper extremities = 0.2, trunk = 0.3, lower extremities = 0.4. For children under 8 years, the weights adjust to 0.2, 0.2, 0.3, and 0.3 respectively.
An EASI score of 0 indicates clear skin with no disease activity. Scores of 0.1 to 1 are classified as almost clear, 1.1 to 7 as mild, 7.1 to 21 as moderate, 21.1 to 50 as severe, and 50.1 to 72 as very severe atopic dermatitis. The theoretical maximum score is 72.
The EASI was developed by modifying the PASI scoring system for use in eczema. While both assess four body regions with area and severity scoring, the EASI evaluates four severity characteristics (erythema, edema/papulation, excoriation, lichenification) compared to the PASI's three (erythema, induration, desquamation). The EASI also uses different severity grades (0 to 3) compared to the PASI (0 to 4), and includes pediatric weight adjustments.

Getting Started

A physician referral is required to access our medical services. Contact your primary care provider to begin the referral process.