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A review of niacinamide, an amide of vitamin B3, examining its mechanisms of action and the evidence for its topical use in treating various dermatological conditions.
Source: Wohlrab J, Kreft D. "Niacinamide - mechanisms of action and its topical use in dermatology." Skin Pharmacology and Physiology. 2014;27(6):311-5. doi: 10.1159/000359974.
Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photoprotective, sebostatic, and lightening effects depending on its concentration. Within a complex metabolic system, niacinamide controls NFkB-mediated transcription of signalling molecules by inhibiting nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects.
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